YourBrain is going Nowhere

Nowhere logoThe Nowhere festival takes place in Spain from 3rd to 8th July. I’m going and maybe you should come too. It is in the middle of a desert and it’s a festival made by it’s attendees. If you’ve heard of Burning Man then imagine the same thing only smaller and with less burning (damn those European fire regulations). In fact, Nowhere is a European regional Burning Man and is built by Burning Man veterans and plenty of others based in Europe, who like the idea but can’t afford to go to Nevada (or missed out in the ticket lottery). Nowhere follows the same format.

Nowhere is built on the principles of:

Not wanting to be left out, and since I can’t make art, I’ve decided to run a few drugs workshops. Burning Man was founded by San Francisco hippies, so needless to say, drugs are inevitable/integral part of the festival. It also has a tradition of hosting talks and discussions all about them from luminaries in the field. They’ve had  Ann & Sasha Shulgin, Rick Doblin of MAPS, Daniel Pinchbeck of Reality Sandwich and many others. It would be nice if Nowhere had the same engagement with the European psychedelic community. So I’d encourage all of you with an interest in self-experimentation to come along.

This year to get things moving, I’m going to be giving a short talk every afternoon at 4:20 pm.

Tues 3rd July 4:20pm
A new golden age for recreational drugs? 
Spice, Mephedrone, Methoxetamine are just the tip of a very large iceberg. In the last 6 years, nearly 200 brand new chemicals been have taken recreationally in Europe. Where do they come from? Clandestine labs in china and elsewhere. How do I get them? Your best bet is the internet. What exactly are they and what do they do? We are only just beginning to find out.
Wed 4th July
Studying drug use with smartphones
In my own research, I’ve been building smartphone apps to study recreational drug users as they are actually getting intoxicated. The Boozerlyzer is our first app. It’s a completely free app on Android that tracks what you’ve drunk, how it is making you feel. Using fun simple games it can also measure how your memory, coordination and reaction time are effected.
Thurs 5th July 4:20pm
Marijuana really is a medicine.
Perhaps like me you thought medical marijuana wasn’t really a ‘medicine’? Think again. Medical marijuana does more than just relieve the pain and improve the mood of its users. It has real positive and measurable effects on the symptoms of many serious medical conditions. Patients with over 100 different conditions ranging from arthritis and insomnia to MS and HIV. It may even cure cancers. Yet research and patients are still hamstrung by marijuana’s illegal status.
Fri 6th July 4:20pm
Psychedelic therapies, at last.
Thanks to the hard work of MAPS, the multidisciplinary assocation for psychedelic studies, governments are finally letting doctors, therapists and researchers investigate the potential benefits of psychedelic therapies. Many exciting projects are underway looking at using psilocybin to treat depression, MDMA to treat post-traumatic stress disorder, LSD may treat cluster headaches and fear of death in cancer patients.
Sat 7th July 4:20pm
This is your brain on psychedelics.
British researchers recently gave people magic mushrooms and put them in a brain scanner. It was the first research with psychedelics allowed in the UK in 40 years and the first time anyone, anywhere had done anything like this. What they found surprised everyone, including them. The results were exactly the opposite from what everyone had been predicting. But what they found could finally explain how psychedelics work and even help treat depression and give insight into near death experiences.

There will also be dancing, mudfights and nakedness. What’s not to love?

 

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The surprising effectiveness of medical marijuana

The other highly surprising thing I learnt at the recent SSDP UK conference was just how amazingly effective cannabis is as a medicine. Obviously, I knew that marijuana was available as ‘medicine’ in some countries and US states. But I largely thought the quotation marks were serving a purpose. While I had no doubt that it was a good psychic remedy. If it was at all genuinely medicinal, I had the vague idea that it’s main benefits were largely secondary, a palliative that helps managed pain and nausea.  In fact, medical marijuana does a lot more than that. A hell of a lot more. To give you some idea take a look at this list of over a hundred treatable conditions. And it really is treatment, not just management of pain and other side effects. It may even cure cancer.

The point was brought forcefully home to me at the conference by two patient/activists,  Clark French and Greg de Hoedt, who hosted a panel on their own experiences. Clark French has multiple sclerosis and has at times been confined to a wheelchair by his condition. Taking regular medications certainly helped his condition but often with numerous unpleasant side effects, which then required more drugs with more side effects. Before trying medical marijuana he was on a cocktail of 11 different medications and he was still sick. Then he discovered that marijuana helped with every single symptom. Since then he has visited California to talk to medical marijuana professionals and discover which strains would work best for him. His MS is still there but it is much more under control and as a result of using marijuana he has cut down to just one other medication.

Discount Medical Marijuana cannabis shop at 97...

Discount Medical Marijuana cannabis shop at 970 Lincoln Street, Denver, Colorado. (Photo credit: Wikipedia)

Greg de Hoedt has found marijuana to be equally effective in helping him manage his Crohn’s Disease. Greg is a documentary filmmaker, video blogger and activist. After discovering that cannabis was the one of the best medicines for his condition, Greg set up Cannabis Cure UK, an advocacy group for patients who benefit from their use of marijuana. He has quit his job and works full time on health and advocacy. He spent 6 months in California documenting and learning about the legal medical marijuana market that has existed for over a decade and meeting the community associated with it. Since returning he has started a documentary covering the challenges faced patients trying to do the same in the UK whilst marijuana remains illegal. The latest venture from Cannabis Cure UK involves the promotion of regional Cannabis Social Clubs to support patients socially, medcially and politcally.

No one really knows why cannabis is such an effective medicine against such a wide range of diseases. One possibility might be due to it’s similarity to the body’s own signalling chemicals known as endocannabinoids, Natually occuring chemicals in the body that have similar chemical structure to tetrahydrocannabinol (THC) and cannabidiol (CBD), the active chemicals in marijuana. Meaning that cannabis could affect the same cannibinoid receptors found on the surface of many cells.  Endocannibinoids and the corresponding receptor system were first discovered in the 1980′s and research into them has only really taken off in the last ten years. But they are now very much a hot topic in both neuroscience and pharmacology.

That’s because there appear to be two classes of cannibinoid receptors CB1 and CB2. CB1 receptors are found on the surface of cell in the central nervous system. CB2 receptors are found mainly in the immune system. CB1 receptors are of great interest to neuroscience and very likely that it is due them that cannabis has its psychoactive effects. The effects of CB2 on the immune system may help explain its remarkable medicinal properties, particularly its beneficial effects for many auto-immune disorders like MS and Crohn’s disease.

However, the truth is that at this point in time, very little is know about either the body’s natural cannibinoid system nor the effects that marijuana can have on it. There’s a great amount of anecdotal evidence from patients who have been helped and a growing list of scientific studies verifying this. But a lot more research is needed. At the moment this research is severely hampered by marijuana illegal status in most of the world. Even in those states in the US where medical marijuana is permitted, research cannot be carried out because at a national/federal level marijuna remains a schedule one drug, said to have no medical benefits.

Knowing this, I now understand a little bit better why medical marijuana is more than just something to make people ‘feel better’, why people with very serious conditions are risking jail to get their medicine and why we need more activism and advocacy in this area.

Clearing the Smoke: The Science of Cannabis | Watch Free Documentary Online.

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Drugs Quote #021 – HHGttG on alcohol


‘The Encyclopedia Galactica’ describes alcohol as a colourless, volatile liquid formed by the fermentation of sugars and also notes its intoxicating effect on certain carbon-based life forms. ‘The Hitch-Hiker’s Guide to the Galaxy’ also mentions alcohol. It says that the best drink in existence is the Pan-Galactic Gargle Blaster. The effect of which is like “having your brain smashed out by a slice of lemon wrapped round a large gold brick.” The Guide also tells you on which planets the best Pan-Galactic Gargle Blasters are mixed, how much you can expect to pay for one, and what voluntary organizations exist to help you rehabilitate.

via The Hitch-Hiker’s Guide to the Galaxy – Part 1.

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Imaging the brain on psychedelics – Dr. Robin Carhart-Harris

Dr. Robin Carhart-Harris is one of the first researchers in 40 years to be allowed to investigate the effects of psychedelic drugs. He used a FMI brain imager to study the resting state activation in the brains of volunteers how had taken a fairly small but very intense intravenous dose of psilocybin (found in magic mushrooms). What he found surprised everyone. He found that the drug caused large decreases in activity in various centres of coordination in the brain. This was exactly the opposite to what Robin and everyone else had been predicting but it is a very clear and very robust finding. What’s more the result does seem to explain a lot of the phenomenology of psychedelic experience.

In this recent talk for the Ecology, Cosmos and Consciousness lecture series at the October Gallery, Robin gives a very accessible account of his fascinating and first rate ongoing research. If you are at all interested in what is happening to the brain during psychedelic experience you really should watch this talk. Because for the first time in human history we are starting to get something of a clue.

This talk describes the research Robin has been carrying out over the last few years involving brain imaging and psychedelics. This work has been motivated by Amanda Feilding and the Beckley Foundation and done under the mentorship of Prof David Nutt and with the support of Imperial College London and the Universities of Bristol and Cardiff. Robin describes the rationale, results and implications of their imaging work with psilocybin (magic mushrooms), the early results of an ongoing study with MDMA (ecstasy) and the design of a planned study to assess psilocybin as a treatment for depression. The scientific content is presented in an accessible way with the hope of stimulating an interest into the neurobiology of psychedelics and their potential therapeutic action.

via Psychedelics and Brain Imaging – Dr Robin Carhart-Harris on Vimeo.

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Quantified Self & Boozerlyer in the Economist

The Economist has a nice article about the Quantified Self movement and their recent conference in Amsterdam. The Boozerlyzer gets a passing mention.

Quantified Self LogoTHE idea of measuring things to chart progress towards a goal is commonplace in large organisations. Governments tot up trade figures, hospital waiting times and exam results; companies measure their turnover, profits and inventory. But the use of metrics by individuals is rather less widespread, with the notable exceptions of people who are trying to lose weight or improve their fitness. Most people do not routinely record their moods, sleeping patterns or activity levels, track how much alcohol or caffeine they drink or chart how often they walk the dog.

Many people mentioned Boozerlyzer, an app for Android smartphones that helps people track their drinking and uses simple games to help them measure the effect of alcohol on their co-ordination, reaction times, memory and emotions. And there was much talk of the potential to encourage self-tracking through “gamification”—turning everyday activities into games by awarding points and trophies and encouraging people to compete with their friends.

via The quantified self: Counting every moment | The Economist.

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Beware the Bromo-Dragonfly

Safe to eat.

2D structure of psychedelic drug R-Bromo-Drago...

Less safe - Bromo-DragonFLY can prove deadly

One interesting new thing I learnt at the SSDP-UK annual conference this weekend is that Bromo-Dragonfly is extremely dangerous.

Bromo-Dragonfly is a very highly potent psychedelic, so called because of the shape of its molecule. It is one of the most recently discovered ‘legal highs’ and has been responsible for a growing number of deaths

At least five deaths and dozens of hospitalizations, for instance, are believed to have been caused by a compound called Bromo-Dragonfly that was first developed in Nichols’s Purdue lab and is now produced for Westerners in China.

In one fatal 2009 batch, a San Jose man died after consuming Chinese-made Bromo that contained “unspecified synthesis impurities,” which may have contributed to the product’s toxicity, according to the underground drug user website Erowid. His distributor sent more of that batch to other users in Denmark and Spain, leading to at least one other death and numerous hospitalizations. And just last May, a Chinese manufacturer sent a college student in Oklahoma a mislabeled batch of Bromo when he had ordered a far less potent product. As a result, two more people died and six others were hospitalized after overdosing.

via Juicers, Trippers, and Crocodiles: The Dangerous World of Underground Chemistry | Drugs & Addiction | DISCOVER Magazine.

All of these deaths have been accidental. Classic cases of ‘death by misadventure’, they do highlight the need for some form of regulation of the legal highs market.

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Boozerlyzer beta!

It has taken a while but our first beta version is finally available.

Beta Version 40 

  • Speed & reliability improved.
  • Can now edit and delete drinks.
  • New data plots
    - drinks per session or over last week
    - scatter plots of mood versus alcohol
    - scatter plots of score, speed, coordination by game (not fully working yet)
  • Improved help menus and game instructions
  • Updated for Titanium 2.0

You can get it in Android marketplace  (now called Google Play).

 

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Drugs Quote #020 – William Shakespeare

Cobbe portrait, claimed to be a portrait of Wi...

Cobbe portrait, claimed to be a portrait of William Shakespeare done while he was alive Lëtzebuergesch: Uelegporträt vum William Shakespeare am Alter vu 46 Joer, gemoolt 1610 zu Liefzäite vum Dichter, haut am Besëtz vum Konschtrestaurator Alec Cobbe. (Photo credit: Wikipedia)

Since today is Shakespeare’s [approx birthday] and death-day, here he is explaining alcohol.

MACDUFF
Was it so late, friend, ere you went to bed,
That you do lie so late?

Porter
‘Faith sir, we were carousing till the second cock;
and drink, sir, is a great provoker of three things.

MACDUFF
What three things does drink especially provoke?

Porter
Marry, sir, nose-painting, sleep, and urine.
Lechery, sir, it provokes, and unprovokes; it provokes
the desire, but it takes away the performance. There-
fore, much drink may be said to be an equivocator
with lechery: it makes him, and it mars him; it sets him
on, and it takes him off; it persuades him, and dis-
heartens him; makes him stand to, and not stand to; in
conclusion, equivocates him in a sleep, and, giving him
the lie, leaves him.

Macbeth, ACT 2, Scene 3

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Boozerlyzer won’t be at TED 2013

A few weeks a go I sent in a very short audition video for TED 2013. I didn’t get in which is probably just as well because I’d have been terrified. But I thought you might like to see it. Naturally enough it was filmed in my local pub, the Prince Albert, Brixton.

In case you aren’t familiar with TED, here’s a taste of TED 2012

via KreativKiez Neukölln: A Taste of TED2012.

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Tom Lehrer – The Old Dope Peddler

Today is Tom Lehrer’s 84th birthday :)

When the shades of night are falling,
Comes a fellow ev’ryone knows,
It’s the old dope peddler,
Spreading joy wherever he goes.
Ev’ry evening you will find him,
Around our neighborhood.
It’s the old dope peddler
Doing well by doing good.

He gives the kids free samples,
Because he knows full well
That today’s young innocent faces
Will be tomorrow’s clientele.
Here’s a cure for all your troubles,
Here’s an end to all distress.
It’s the old dope peddler
With his powdered ha-happiness.

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